Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients.

@article{Yamabe1997DownregulationOT,
  title={Down-regulation of the defective transcripts of the Werner's syndrome gene in the cells of patients.},
  author={Yukako Yamabe and Masamichi Sugimoto and Misako Satoh and Noboru Suzuki and Masae Sugawara and Makoto Goto and Yasuhiro Furuichi},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={236 1},
  pages={151-4}
}
Werner's syndrome (WS), an adult progeria, is a recessive genetic disorder caused by the mutations in the DNA helicase gene (WRN). In this study, a comparative northern blot analysis was made for poly(A)+ RNAs extracted from fibroblasts and B-lymphoblastoid cells of WS patients, relatives of patients, and normal individuals. The levels of mutant WRN mRNA from patient cells were significantly lower than those of intact mRNA from the cells of normal individuals by an average of 70%. Furthermore… CONTINUE READING

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