Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes.

@article{Gebhard2004DownregulationOT,
  title={Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes.},
  author={Pia Margarethe Gebhard and Stephan Soeder and Brigitte Bau and Thomas Aigner},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2004},
  volume={9},
  pages={827-33}
}
Anabolic activity, phenotypic alterations, and in particular survival of the chondrocytes are essential for the maintenance of proper articular cartilage and appears to fail during osteoarthritic cartilage degeneration. In this study, we investigated the presence and expression of RhoB in adult human articular cartilage and its regulation in osteoarthritic cartilage as well as in chondrocytes in vitro. RhoB belongs to the family of small GTPases, which are thought to be involved in a large… CONTINUE READING

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