Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth.

@article{Chen2000DownregulationOS,
  title={Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth.},
  author={Jun Chen and Wen-Juan Wu and Stephen K. Tahir and Paul E. Kroeger and Saul H. Rosenberg and Lex M. Cowsert and Frank H Bennett and Stanislaw Krajewski and Maryla Krajewska and Katherine M. Welsh and John C. Reed and Shi Chung Ng},
  journal={Neoplasia},
  year={2000},
  volume={2 3},
  pages={235-41}
}
Survivin, a member of the inhibitor of apoptosis protein (IAP) family, is detected in most common human cancers but not in adjacent normal cells. Previous studies suggest that survivin associates with the mitotic spindle and directly inhibits caspase activity. To further investigate the function of survivin, we used a survivin antisense (AS) oligonucleotide to downregulate survivin expression in normal and cancer cells. We found that inhibition of survivin expression increased apoptosis and… CONTINUE READING

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