Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors.

  title={Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors.},
  author={Kurt J Griffin and Lawrence S. Kirschner and Ludmila Matyakhina and Sotirios Stergiopoulos and Audrey J. Robinson-White and Sara M. Lenherr and Frank D Weinberg and Edward S. Claflin and Elise M Meoli and Y S Cho-chung and Constantine A Stratakis},
  journal={Cancer research},
  volume={64 24},
Mutations of the human type Ialpha regulatory subunit (RIalpha) of cyclic AMP-dependent protein kinase (PKA; PRKAR1A) lead to altered kinase activity, primary pigmented nodular adrenocortical disease, and tumors of the thyroid and other tissues. To bypass the early embryonic lethality of Prkar1a(-/-) mice, we established transgenic mice carrying an antisense transgene for Prkar1a exon 2 (X2AS) under the control of a tetracycline-responsive promoter. Down-regulation of Prkar1a by up to 70% was… CONTINUE READING


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