Down-regulation of protein kinase Ceta potentiates the cytotoxic effects of exogenous tumor necrosis factor-related apoptosis-inducing ligand in PC-3 prostate cancer cells.

@article{Sonnemann2004DownregulationOP,
  title={Down-regulation of protein kinase Ceta potentiates the cytotoxic effects of exogenous tumor necrosis factor-related apoptosis-inducing ligand in PC-3 prostate cancer cells.},
  author={J{\"u}rgen Sonnemann and Volker Gekeler and Antje Sagrauske and Cornelia E M{\"u}ller and H Hofmann and James F. Beck},
  journal={Molecular cancer therapeutics},
  year={2004},
  volume={3 7},
  pages={773-81}
}
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a highly promising candidate for the treatment of cancer because it elicits cell death in the majority of tumor cells while sparing most normal cells. Some cancers, however, display resistance to TRAIL, suggesting that treatment with TRAIL alone may be insufficient for cancer therapy. In the present study, we explored whether the apoptotic responsiveness of PC-3 prostate cancer cells to TRAIL could be enhanced by targeting the… CONTINUE READING