Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1.

  title={Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1.},
  author={Yingjie Wang and Yixing Zhou and Katalin Zsuzsanna Szab{\'o} and Carol Renfrew Haft and JoAnn Trejo},
  journal={Molecular biology of the cell},
  volume={13 6},
Degradation or "down-regulation" of protease-activated receptor-1 (PAR1), a G protein-coupled receptor for thrombin, is critical for termination of receptor signaling. Toward understanding the molecular mechanisms by which activated PAR1 is internalized, sorted to lysosomes, and degraded, we investigated whether PAR1 interacted with sorting nexin 1 (SNX1). SNX1 is a membrane-associated protein that functions in lysosomal sorting of the epidermal growth factor receptor. In vitro biochemical… CONTINUE READING
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Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors

  • C. R. Haft, M. Sierra, V. A. Barr, D. H. Haft, S. I. Taylor
  • Mol.Cell. Biol
  • 1998
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