Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix.

@article{Halmos1996DownregulationOP,
  title={Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix.},
  author={G Halmos and Andrew V Schally and J Pinski and Manuel Vadillo-Buenfil and K Groot},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 6},
  pages={2398-402}
}
  • G Halmos, Andrew V Schally, +2 authors K Groot
  • Published 1996 in
    Proceedings of the National Academy of Sciences…
Antagonists of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid secretion immediately after administration, without initial stimulatory effects. [Ac-D-Nal(2)1,D-Ph(4Cl)2,D-Pal(3)3,D-Cit6,D-Ala10]LH-R H (SB-75; Cetrorelix) is a modern, potent antagonistic analog of LH-RH. In this study, the binding characteristics of receptors for LH-RH in membrane fractions from rat anterior pituitaries were investigated after a single injection of… CONTINUE READING