Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells.

Abstract

Estrogens and antiestrogens influence the G(1) phase of the cell cycle. In MCF-7 breast cancer cells, estrogen stimulated cell cycle progression through loss of the kinase inhibitor proteins (KIPs) p27 and p21 and through G(1) cyclin-dependent kinase (cdk) activation. Treatment with antiestrogen drugs, Tamoxifen or ICI 182780, caused cell cycle arrest, with… (More)

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@article{Cariou2000DownregulationOP, title={Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells.}, author={Sandrine Cariou and Judith C. Donovan and W. Michael Flanagan and Astrid Mili{\'c} and Nandita Bhattacharya and Joyce M Slingerland}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2000}, volume={97 16}, pages={9042-6} }