Down-regulation of nitrergic transmission in the rat striatum after chronic nigrostriatal deafferentation.

@article{Sancesario2004DownregulationON,
  title={Down-regulation of nitrergic transmission in the rat striatum after chronic nigrostriatal deafferentation.},
  author={Giuseppe Sancesario and Mauro Giorgi and Vincenza D'angelo and Anna Modica and Alessandro Martorana and Maria Morello and C Peter Bengtson and Giorgio Bernardi},
  journal={The European journal of neuroscience},
  year={2004},
  volume={20 4},
  pages={989-1000}
}
Dopamine and NO are physiological stimulators of synthesis of cAMP and cGMP, respectively, and NO synthase-containing interneurons in the striatum are physiologically activated by dopamine-containing neurons in the substantia nigra. This study investigated whether lesioning dopamine neurons has multiple consequences in the striatum consistent with the reported sensitization of cAMP synthesis, including alteration of the NO-cGMP pathway and phosphodiesterase-dependent metabolism of cyclic… CONTINUE READING

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