Down regulation of murine MHC class I expression by bovine herpesvirus 1.

@article{Hariharan1993DownRO,
  title={Down regulation of murine MHC class I expression by bovine herpesvirus 1.},
  author={Mangala J Hariharan and Chandra Nataraj and Subramaniam Srikumaran},
  journal={Viral immunology},
  year={1993},
  volume={6 4},
  pages={273-84}
}
The objective of this study was to investigate the effect(s) of bovine herpesvirus 1 (BHV-1) infection on the expression of MHC class I molecules in murine fibroblasts. L-cells were infected with BHV-1 at a multiplicity of infection (m.o.i.) of 10 plaque forming units (PFU) per cell, and the expression of MHC class I molecules was analyzed by flow cytometry and immunoprecipitation. Temporal studies revealed a reduction in class I expression beginning at 8 h post infection (p.i.) which reached a… CONTINUE READING

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