Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans.

@article{Larsson1997DownregulationOM,
  title={Down-regulation of mitochondrial transcription factor A during spermatogenesis in humans.},
  author={N-G. Larsson and Anders Oldfors and J. David Garman and Gregory S Barsh and D. A. Clayton},
  journal={Human molecular genetics},
  year={1997},
  volume={6 2},
  pages={185-91}
}
Mitochondrial transcription factor A (mtTFA) is a key activator of mitochondrial transcription in mammals. It also has a role in mitochondrial DNA (mtDNA) replication, since transcription generates an RNA primer necessary for initiation of mtDNA replication. In the mouse, testis-specific mtTFA transcripts encode a protein isoform that is imported to the nucleus rather than into mitochondria of spermatocytes and elongating spermatids. We now report molecular characterization of human mtTFA (h… CONTINUE READING

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Low levels of mitochondrial transcription factor A in mitochondrial DNA depletion

  • Larsson, N.-G, A. Oldfors, E. Holme, D. A. Clayton
  • Biochem. Biophys. Res. Commun
  • 1994

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