Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1.

@article{Zhang2014DownregulationOM,
  title={Down-regulation of miR-34a alleviates mesangial proliferation in vitro and glomerular hypertrophy in early diabetic nephropathy mice by targeting GAS1.},
  author={Le Zhang and Siyi He and Shaodong Guo and Wei Fen Xie and Rong Xin and Hua Yu and Fan Yang and Jing Qiu and Di Zhang and Shiwen Zhou and Kebin Zhang},
  journal={Journal of diabetes and its complications},
  year={2014},
  volume={28 3},
  pages={259-64}
}
AIMS Diabetic nephropathy (DN) is a major diabetic complication characterized by mesangial proliferation and glomerular hypertrophy. MicroRNAs might play an important role in these pathological processes. The aim of this study is to examine the possible association of miR-34a as one of the microRNAs with DN and underlying mechanisms in vitro and in vivo. METHODS According to previous results of microarray which compared the different microRNAs between diabetic and normal control mice, miR-34a… CONTINUE READING

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