Down-regulation of miR-124/-214 in cutaneous squamous cell carcinoma mediates abnormal cell proliferation via the induction of ERK

@article{Yamane2012DownregulationOM,
  title={Down-regulation of miR-124/-214 in cutaneous squamous cell carcinoma mediates abnormal cell proliferation via the induction of ERK},
  author={Keitaro Yamane and Masatoshi Jinnin and Tomomi Etoh and Yuki Kobayashi and Naoki Shimozono and Satoshi Fukushima and Shinichi Masuguchi and Keishi Maruo and Yuji Inoue and Tsuyoshi Ishihara and Jun Aoi and Yuichi Oike and Hironobu Ihn},
  journal={Journal of Molecular Medicine},
  year={2012},
  volume={91},
  pages={69-81}
}
Squamous cell carcinoma (SCC) is one of the most common skin cancers. Because its potential to recur and metastasize leads to a poor prognosis and significant mortality, it is necessary to develop new early diagnostic tools and new therapeutic approaches. In this study, we found protein levels of ERK1 and ERK2 were increased in SCC cell lines without changing mRNA levels and that ERK1/2 mediates abnormal cell proliferation in these cells. Then, mechanisms underlying the overexpression of ERK1/2… CONTINUE READING
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