Down-regulation of mannose receptors on macrophages after infection with Leishmania donovani.

@article{Basu1991DownregulationOM,
  title={Down-regulation of mannose receptors on macrophages after infection with Leishmania donovani.},
  author={N K Basu and Rina Sett and Pijush K. Das},
  journal={The Biochemical journal},
  year={1991},
  volume={277 ( Pt 2)},
  pages={451-6}
}
Macrophages express a mannose-specific endocytosis receptor that binds and internalizes mannose-terminated glycoproteins. Infection of mouse peritoneal macrophages with Leishmania donovani resulted in a decrease in mannose-receptor activity. With 125I-labelled beta-glucuronidase as ligand, a 2-fold decrease in uptake rate was observed in infected cells… CONTINUE READING