Down-regulation of mRNAs for synaptic adhesion molecules neuroligin-2 and -3 and synCAM1 in spinal motoneurons after axotomy.

@article{Zelano2007DownregulationOM,
  title={Down-regulation of mRNAs for synaptic adhesion molecules neuroligin-2 and -3 and synCAM1 in spinal motoneurons after axotomy.},
  author={Johan Zelano and Wilhelm Wallquist and Nils P. Hailer and Staffan Cullheim},
  journal={The Journal of comparative neurology},
  year={2007},
  volume={503 2},
  pages={308-18}
}
After peripheral axotomy, synapses are eliminated from the somata of spinal motoneurons. Recent evidence indicates that synaptic adhesion molecules play a role in maintenance of synaptic contacts, but so far such molecules have not been investigated in the context of synapse elimination after injury. In vitro, the neuroligins (NLGs) and SynCAM1 drive formation of synapses, and RNAi of NLGs results in decreased synaptic input, indicating an important role for these molecules in synaptic biology… CONTINUE READING
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