Down-regulation of laminin-5 in breast carcinoma cells.

  title={Down-regulation of laminin-5 in breast carcinoma cells.},
  author={Katherine J. Martin and C P Kwan and Kazuhito Nagasaki and X Zhang and M J O'hare and Carolyn M. Kaelin and Robert E. Burgeson and Arthur B. Pardee and Ruth Sager},
  journal={Molecular medicine},
  volume={4 9},
BACKGROUND Laminin-5 (ln-5), a large heterotrimeric glycoprotein consisting of an alpha 3, beta 3, and gamma 2 chain, is a component of epithelial cell basement membranes that functions as a ligand of the alpha 3 beta 1 and alpha 6 beta 4 integrins to regulate cell adhesion, migration, and morphogenesis. The ln-5 chains show tissue-specific patterns of regulation in tumors derived from different tissues. For example, ln-5 is often up-regulated in gliomas, gastric carcinomas, and squamous… CONTINUE READING


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