Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy.

@article{Benito2008DownregulationOI,
  title={Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy.},
  author={Jos{\'e} Miguel Benito and Mariola L{\'o}pez and Sara Lozano and J. Gonz{\'a}lez-lahoz and Vicente Soriano},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={198 10},
  pages={1466-73}
}
BACKGROUND Factors influencing the depletion of CD4(+) cells and the restoration of CD4(+) cells after antiretroviral therapy are not completely understood. Recently, attention has been paid to interleukin (IL)-7 and its receptor (CD127). We analyzed the influence of T cell activation and of suppression of viremia with antiretroviral therapy on this system, as well as its role in CD4(+) cell restoration after long-term antiretroviral therapy. METHODS IL-7 levels and CD127 expression on… CONTINUE READING
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