Down-regulation of interleukin-2 production by CD4(+) T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription.

@article{Lee2012DownregulationOI,
  title={Down-regulation of interleukin-2 production by CD4(+) T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription.},
  author={Mi Jin Lee and M Y Woo and Y. J. Chwae and Myung-Hee Kwon and Kyongmin Kim and Sun Park},
  journal={Immunobiology},
  year={2012},
  volume={217 10},
  pages={986-95}
}
TIM-3 is expressed by TH1 cells and negatively regulates cytokine production by these cells. The aim of the present study was to explore the mechanisms by which IL-2 production is suppressed in TIM-3-expressing T cells. First, the activity of two transcription factors that bind to the IL-2 promoter was examined in Jurkat T cells expressing TIM-3. Both AP-1 and NFAT activity were reduced in TIM-3-expressing cells stimulated with a phorbol ester and a calcium ionophore. At the same time… CONTINUE READING