Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid.

@article{Lauwerys2013DownregulationOI,
  title={Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α-kinoid.},
  author={Bernard R Lauwerys and {\'E}ric Hachulla and François Spertini and E Quintanilla L{\'a}zaro and Christian Jorgensen and Xavier Mariette and Edwige Haelterman and G{\'e}raldine Grouard-Vogel and Bernard Fanget and Olivier Dhellin and Pierre G Vandepapeli{\`e}re and Fr{\'e}d{\'e}ric A. Houssiau},
  journal={Arthritis and rheumatism},
  year={2013},
  volume={65 2},
  pages={447-56}
}
OBJECTIVE We developed interferon-α-kinoid (IFN-K), a drug composed of inactivated IFNα coupled to a carrier protein, keyhole limpet hemocyanin. In human IFNα-transgenic mice, IFN-K induces polyclonal antibodies that neutralize all 13 subtypes of human IFNα. We also previously demonstrated that IFN-K slows disease progression in a mouse model of systemic lupus erythematosus (SLE). This study was undertaken to examine the safety, immunogenicity, and biologic effects of active immunization with… CONTINUE READING
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IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model.

Proceedings of the National Academy of Sciences of the United States of America • 2009
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