Down-regulation of integrin alpha(v)beta(3) expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes.

@article{Adachi2001DownregulationOI,
  title={Down-regulation of integrin alpha(v)beta(3) expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes.},
  author={Yoshifumi Adachi and S. Lakka and Nirmala Chandrasekar and Niranjan Yanamandra and Christopher S. Gondi and Sanjeeva Mohanam and Dzung H. Dinh and William C. Olivero and Meena Gujrati and Takashi Tamiya and Takashi Ohmoto and Gregorios P. Kouraklis and Bharat Aggarwal and Jasti S. Rao},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 50},
  pages={
          47171-7
        }
}
Interaction between the extracellular matrix and integrin receptors on cell surfaces leads not only to cell adhesion but also to intracellular signaling events that affect cell migration, proliferation, and survival. The vitronectin receptor alpha(v)beta(3) integrin is of key importance in glioma cell biology. The expression of urokinase-type plasminogen activator receptor (uPAR) was recently shown to co-regulate with the expression of alpha(v)beta(3) integrin. Moreover, restoration of the p16… CONTINUE READING
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