Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes.

@article{Kou2013DownregulationOI,
  title={Down-regulation of insulin signaling is involved in painful diabetic neuropathy in type 2 diabetes.},
  author={Zhen-zhen Kou and Chun-yu Li and Jun Tang and Jia-Chen Hu and Juan Qu and Yong-Hui Liao and Sheng-xi Wu and Hui Li and Yun-qing Li},
  journal={Pain physician},
  year={2013},
  volume={16 2},
  pages={E71-83}
}
BACKGROUND Previous theories considered that the main cause of painful diabetic neuropathy (PDN) was due to hyperglycemia. However, recent evidence indicated that hyperinsulinemia plays a greater role in type 2 diabetic metabolisms (T2DM). OBJECTIVES Our aim was to explore insulin signaling to determine the molecular mechanism involved in the pathogenesis of PDN in T2DM. STUDY DESIGN A randomized, double blind, controlled animal trial. METHODS We observed the localization of insulin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Similar Papers

Loading similar papers…