Down-regulation of hypoxia-inducible factor-1alpha by hyperbaric oxygen attenuates the severity of acute pancreatitis in rats.

@article{Bai2009DownregulationOH,
  title={Down-regulation of hypoxia-inducible factor-1alpha by hyperbaric oxygen attenuates the severity of acute pancreatitis in rats.},
  author={Xuewei Bai and Bei Sun and Shangha Pan and HongChi Jiang and Feng Wang and Geoffrey Wayne Krissansen and Xueying Sun},
  journal={Pancreas},
  year={2009},
  volume={38 5},
  pages={515-22}
}
OBJECTIVES This study investigated the role of hypoxia-inducible factor 1alpha (HIF-1alpha) in acute pancreatitis (AP) and whether HIF-1alpha is involved in the therapeutic effects of hyperbaric oxygen (HBO) on AP. METHODS Thirty Wistar rats with taurocholate-induced AP were randomly assigned to 3 groups (each group had 10 rats) receiving oxygen, HBO, or no therapeutic treatment 4 hours after induction. Ten healthy sham-operated rats also served as controls. The arterial oxygen saturation… CONTINUE READING