Down-regulation of hypoxia inducible factor-1alpha: a possible explanation for the protective effects of estrogen on genioglossus fatigue resistance.

@article{Jia2010DownregulationOH,
  title={Down-regulation of hypoxia inducible factor-1alpha: a possible explanation for the protective effects of estrogen on genioglossus fatigue resistance.},
  author={Shan-shan Jia and Yue-hua Liu},
  journal={European journal of oral sciences},
  year={2010},
  volume={118 2},
  pages={139-44}
}
Patients with obstructive sleep apnea/hypopnea syndrome (OSAHS) often exhibit fatigued or inefficient upper airway dilator muscle activity. It has been shown that estrogen may have some impact on upper airway contractility under normoxic conditions. Chronic intermittent hypoxia (CIH) is a frequent feature of OSAHS, and it may alter muscle susceptibility to oxidative stress, a characteristic of a fatigable nature. Hypoxia inducible factor-1 (HIF-1) is a transcription factor that is responsible… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 44 references

Obstructive sleep apnea syndrome is a systemic disease

  • C Zamarron, V Garcı́a Paz, A. Riveiro
  • Current evidence. Eur J Intern Med
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…