Down regulation of human positive coactivator 4 suppress tumorigenesis and lung metastasis of osteosarcoma


Osteosarcoma is a kind of primary malignant bone tumor with the highest incidence and an extraordinarily poor prognosis and early pulmonary metastasis formation as a frequent occurrence. Transcriptional positive coactivator 4 (PC4) has multiple functions in DNA replication, transcription, repair and chromatin organization, even in tumorigenesis. However… (More)
DOI: 10.18632/oncotarget.18290