Down-regulation of hepatic and renal 11 beta-hydroxysteroid dehydrogenase in rats with liver cirrhosis.

@article{Escher1998DownregulationOH,
  title={Down-regulation of hepatic and renal 11 beta-hydroxysteroid dehydrogenase in rats with liver cirrhosis.},
  author={Genevie Ve Escher and Artur Nawrocki and Th{\'e}r{\`e}se Staub and Bannikuppe Sannanayak Vishwanath and Brigitte M. Frey and Juerg Reichen and Felix J. Frey},
  journal={Gastroenterology},
  year={1998},
  volume={114 1},
  pages={175-84}
}
BACKGROUND & AIMS 11 beta-Hydroxysteroid dehydrogenase (11 beta-OHSD) enzymes are responsible for the interconversion of active 11 beta-hydroxycorticosteroids into inactive 11-ketoglucocorticosteroids and by that mechanism regulate the intracellular access of the steroids to the cognate receptor. A down-regulation of the shuttle of active to inactive glucocorticoids enhances access of glucocorticosteroids to both the glucocorticoid and the mineralocorticoid receptors. In liver cirrhosis… CONTINUE READING
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