Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions.

@article{Cai1998DownregulationOE,
  title={Down-regulation of epidermal growth factor receptor-signaling pathway by binding of GRP78/BiP to the receptor under glucose-starved stress conditions.},
  author={Bing Cai and Akihiro Tomida and Koji Mikami and Koji Nagata and Takashi Tsuruo},
  journal={Journal of cellular physiology},
  year={1998},
  volume={177 2},
  pages={
          282-8
        }
}
GRP78/BiP, a molecular chaperone in the endoplasmic reticulum, is induced under such adverse conditions for cell survival as glucose starvation. Induction of GRP78 has been shown to coincide with G1 cell cycle arrest, which is an important cellular defense system. In this study, we investigated involvement of GRP78 in the mechanism of growth arrest by using human epidermoid carcinoma A431 cells. Under a chemical stress condition with 2-deoxyglucose, GRP78 was induced 3-4-fold. In the stressed… CONTINUE READING

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