Down-regulation of endothelin-B receptor sites in cavernosal tissue of hypercholesterolaemic rabbits.

@article{Sullivan1998DownregulationOE,
  title={Down-regulation of endothelin-B receptor sites in cavernosal tissue of hypercholesterolaemic rabbits.},
  author={Mark E. Sullivan and Michael Richard Dashwood and Cecil Stanley Thompson and Dimitri P. Mikhailidis and Robert Joseph Morgan},
  journal={British journal of urology},
  year={1998},
  volume={81 1},
  pages={128-34}
}
OBJECTIVE To investigate the density and distribution of endothelin-1 (ET-1) and endothelin receptor subtypes in cavernosal tissue of healthy New Zealand White (NZW) rabbits (controls) and to assess any changes in a genetic model of hypercholesterolaemia (the Watanabe rabbit). MATERIALS AND METHODS Penises were excised from six hypercholesterolaemic (HC) rabbits 6 months after birth. Low- and high-resolution autoradiography was performed on cavernosal sections using radioligands for ET-1… CONTINUE READING

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