Down-regulation of endogenous nitric oxide synthase in late-pregnancy and parturition in the rat hypothalamic magnocellular neurons and neurohypophysis.

@article{Okere1996DownregulationOE,
  title={Down-regulation of endogenous nitric oxide synthase in late-pregnancy and parturition in the rat hypothalamic magnocellular neurons and neurohypophysis.},
  author={Chuma O Okere and Takashi Higuchi},
  journal={Neuroscience letters},
  year={1996},
  volume={220 2},
  pages={133-6}
}
Several recent lines of evidence suggest that nitric oxide (NO) may be an endogenous inhibitory regulator of the neurosecretory mechanism in magnocellular neurons of the paraventricular and the supraoptic nuclei in the hypothalamus. The NO synthase (NOS) system in the hypothalamo-neurohypophysial-axis is regulated in an activity-dependent manner. The present study examined NOS activity in the magnocellular neurons and neurohypophysis during pregnancy and parturition by using the nicotinamide… CONTINUE READING

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