Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells.

@article{Troy1994DownregulationOC,
  title={Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells.},
  author={Carol Troy and Michael L Shelanski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 14},
  pages={6384-7}
}
The discovery of missense mutations leading to reduced enzymatic activity in the copper/zinc superoxide dismutase (SOD1) in human familial amyotrophic lateral sclerosis has heightened interest in the role of free radicals in neurodegenerations but left the mechanisms by which they may cause neuronal death unexplained. We have approached this problem by specifically inhibiting the synthesis of SOD1 in cultured PC12 cells with antisense oligonucleotides. Cell survival in both untreated and nerve… CONTINUE READING

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