Down-regulation of beta-catenin by activated p53.

@article{Sadot2001DownregulationOB,
  title={Down-regulation of beta-catenin by activated p53.},
  author={Einat Sadot and Benjamin Geiger and Moshe Oren and Avri Ben-Ze'ev},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 20},
  pages={6768-81}
}
beta-Catenin is a cytoplasmic protein that participates in the assembly of cell-cell adherens junctions by binding cadherins to the actin cytoskeleton. In addition, it is a key component of the Wnt signaling pathway. Activation of this pathway triggers the accumulation of beta-catenin in the nucleus, where it activates the transcription of target genes. Abnormal accumulation of beta-catenin is characteristic of various types of cancer and is caused by mutations either in the adenomatous… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 84 extracted citations

Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2

Journal of experimental & clinical cancer research : CR • 2008
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…