Down-regulation of bcl-2 is associated with p16INK4-mediated apoptosis in non-small cell lung cancer cells

Abstract

We introduced a functional p16 cDNA into non-small cell lung cancer (NSCLC) cell lines expressing different combinations of normal and mutated p16, p53, and Rb genes via a recombinant adenovirus to determine the effect of exogenous p16 expression on cell growth. Analysis of p16-deficient cells infected with Adv/p16 identified growth arrest of the cells in… (More)
DOI: 10.1038/sj.onc.1203466

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@article{Kataoka2000DownregulationOB, title={Down-regulation of bcl-2 is associated with p16INK4-mediated apoptosis in non-small cell lung cancer cells}, author={M. Kataoka and Sandra Wiehle and Francis R. Spitz and Gary E. Schumacher and J. A. Roth and Rodrigo Cristiano}, journal={Oncogene}, year={2000}, volume={19}, pages={1589-1595} }