Down-regulation of amyloid-β through AMPK activation by inhibitors of GSK-3β in SH-SY5Y and SH-SY5Y-AβPP695 cells.

Abstract

Glycogen synthase kinase 3β (GSK-3β) plays a critical role in the pathogenesis of Alzheimer's disease (AD), implicating amyloid-β (Aβ) production, neurofibrillary tangle formation, and neuronal apoptosis. The activation of 5' AMP-activated protein kinase (AMPK) has been linked to aberrant processing of amyloid-β protein precursor (AβPP), and AMPK signaling… (More)
DOI: 10.3233/JAD-2012-111649

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@article{Cai2012DownregulationOA, title={Down-regulation of amyloid-β through AMPK activation by inhibitors of GSK-3β in SH-SY5Y and SH-SY5Y-AβPP695 cells.}, author={Zhiyou Cai and Benyi Li and Keshen Li and Bin Zhao}, journal={Journal of Alzheimer's disease : JAD}, year={2012}, volume={29 1}, pages={89-98} }