Down-regulation of adhesion molecules and matrix metalloproteinases by ZK 156979 in inflammatory bowel diseases.

@article{Martinesi2010DownregulationOA,
  title={Down-regulation of adhesion molecules and matrix metalloproteinases by ZK 156979 in inflammatory bowel diseases.},
  author={M. Martinesi and C. Treves and A. Bonanomi and M. Milla and S. Bagnoli and U. Zuegel and A. Steinmeyer and M. Stio},
  journal={Clinical immunology},
  year={2010},
  volume={136 1},
  pages={
          51-60
        }
}
Intracellular adhesion molecules and matrix metalloproteinases (MMPs) are up-regulated in intestinal mucosa of patients with inflammatory bowel diseases (IBD), i.e. ulcerative colitis (UC) or Crohn's disease (CD). Our aim was to verify whether the vitamin D analogue ZK 156979 (ZK) down-regulates adhesion molecules, and decreases MMPs production by PBMC of IBD patients. ICAM-1 and LFA-1 levels increase, when PBMC were incubated with PHA or LPS or TNF-alpha, and decrease when these substances… Expand
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References

SHOWING 1-10 OF 44 REFERENCES
Spontaneous and cytokine induced expression and activity of matrix metalloproteinases in human colonic epithelium
Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis.
Expression of matrix metalloproteinases-2 and -9 in intestinal tissue of patients with inflammatory bowel diseases.
  • Q. Gao, M. Meijer, +7 authors H. Verspaget
  • Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2005
Beta2 integrin/ICAM expression in Crohn's disease.
A major role for matrix metalloproteinases in T cell injury in the gut.
...
1
2
3
4
5
...