Down-regulation of RhoE is associated with progression and poor prognosis in hepatocellular carcinoma.

@article{Luo2012DownregulationOR,
  title={Down-regulation of RhoE is associated with progression and poor prognosis in hepatocellular carcinoma.},
  author={Hesan Luo and Zhongyi Dong and Jin-jin Zou and Qin Zeng and Dehua Wu and Li Liu},
  journal={Journal of surgical oncology},
  year={2012},
  volume={105 7},
  pages={699-704}
}
BACKGROUND RhoE is an atypical member of Rho GTPases family, which is a crucial regulator of cytoskeletal dynamics, cell cycle progression, and cell proliferation. Previous studies have reported that RhoE was aberrantly expressed in several human cancers, but the role of RhoE in hepatocellular carcinoma (HCC) remained poor understood. OBJECTIVES This study investigated the expression of RhoE and its clinical significance on the outcome of patients with HCC. METHODS The expression of RhoE… CONTINUE READING
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