Down-regulation of PPARgamma2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis.

@article{Moon2006DownregulationOP,
  title={Down-regulation of PPARgamma2-induced adipogenesis by PEGylated conjugated linoleic acid as the pro-drug: Attenuation of lipid accumulation and reduction of apoptosis.},
  author={Hyo Sun Moon and Hyo Geun Lee and Jee Hee Seo and Charles S Chung and Tae Gyun Kim and Ick Young Kim and Kah Wai Lim and Seong Jin Seo and Yeon Ja Choi and Chong Su Cho},
  journal={Archives of biochemistry and biophysics},
  year={2006},
  volume={456 1},
  pages={19-29}
}
This study is designed to evaluate whether the PEGylated conjugated linoleic acid (PCLA) as the pro-drug can have favorable stability, bioavailability, and anti-adipogenic activity in 3T3-L1 cells for anti-obesity when compared with conjugated linoleic acid (CLA) itself. The CLA was simply coupled to poly(ethylene glycol) (PEG) at the melting state without solvents or catalysts through ester linkages between the carboxylic group of CLA and the hydroxyl group of PEG. To confirm of PCLA as the… CONTINUE READING

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