Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload.

@article{Piquereau2012DownregulationOO,
  title={Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload.},
  author={J{\'e}r{\^o}me Piquereau and Fanny Caffin and Marta Novotov{\'a} and Alexandre Prola and Aurore Garnier and Philippe Mateo and Dominique Fortin and Le Ha Huynh and Val{\'e}rie Nicolas and Marcel V Alavi and Catherine Brenner and R Ventura-clapier and Vladimir Veksler and Fr{\'e}d{\'e}ric Pierre Joubert},
  journal={Cardiovascular research},
  year={2012},
  volume={94 3},
  pages={
          408-17
        }
}
AIMS The optic atrophy 1 (OPA1) protein is an essential protein involved in the fusion of the mitochondrial inner membrane. Despite its high level of expression, the role of OPA1 in the heart is largely unknown. We investigated the role of this protein in Opa1(+/-) mice, having a 50% reduction in OPA1 protein expression in cardiac tissue. METHODS AND RESULTS In mutant mice, cardiac function assessed by echocardiography was not significantly different from that of the Opa1(+/+). Electron and… CONTINUE READING

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