Down-regulation of MTUS1 in human colon tumors.

  title={Down-regulation of MTUS1 in human colon tumors.},
  author={Christina Zuern and Jutta Heimrich and Roland Kaufmann and Konrad Klaus Richter and Utz Settmacher and Christoph Wanner and Jan Galle and Stefan Seibold},
  journal={Oncology reports},
  volume={23 1},
Loss of proliferative control and failure to undergo cellular differentiation are key events during carcinogenesis. We recently identified a new potential tumor suppressor gene named MTUS1 (mitochondrial tumor suppressor 1), down-regulated in undifferentiated tumor cell lines, inhibiting tumor cell proliferation after recombinant over-expression. The aim of this study was to investigate whether MTUS1 is also down-regulated in human tumor tissues, and whether reduced expression of MTUS1 enhances… CONTINUE READING