Down-regulation of MTUS1 in human colon tumors.

@article{Zuern2010DownregulationOM,
  title={Down-regulation of MTUS1 in human colon tumors.},
  author={Christina Zuern and Jutta Heimrich and Roland Kaufmann and Konrad Klaus Richter and Utz Settmacher and Christoph Wanner and Jan Galle and Stefan Seibold},
  journal={Oncology reports},
  year={2010},
  volume={23 1},
  pages={183-9}
}
Loss of proliferative control and failure to undergo cellular differentiation are key events during carcinogenesis. We recently identified a new potential tumor suppressor gene named MTUS1 (mitochondrial tumor suppressor 1), down-regulated in undifferentiated tumor cell lines, inhibiting tumor cell proliferation after recombinant over-expression. The aim of this study was to investigate whether MTUS1 is also down-regulated in human tumor tissues, and whether reduced expression of MTUS1 enhances… CONTINUE READING