Down-regulation of MHC class II receptors of DH82 cells, following infection with Ehrlichia canis.

  title={Down-regulation of MHC class II receptors of DH82 cells, following infection with Ehrlichia canis.},
  author={Shimon Harrus and Trevor Waner and Dinorah Friedmann-Morvinski and Zohar Fishman and Hylton Bark and Alon Harmelin},
  journal={Veterinary immunology and immunopathology},
  volume={96 3-4},
In order to evaluate whether infection with E. canis alters the expression of major histocompatibility complex (MHC) class I and/or MHC class II receptors, and by doing so alters the immune response to the organism, flow cytometry was performed on DH82 cells infected with Ehrlichia canis (90% infection) and on uninfected DH82 cells of the same passage, using anti-canine MHC class I and II antibodies. MHC class II expression was evident in 47.6 and 46.2% (mean 46.9%) of uninfected DH82 cells… CONTINUE READING

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