Down-regulation of Leydig cell insulin-like growth factor-I gene expression by interleukin-1.

@article{Lin1992DownregulationOL,
  title={Down-regulation of Leydig cell insulin-like growth factor-I gene expression by interleukin-1.},
  author={T F Lin and Dongmei Wang and Madan L. Nagpal and William W Chang and Jo H. Calkins},
  journal={Endocrinology},
  year={1992},
  volume={130 3},
  pages={1217-24}
}
We have reported previously that insulin-like growth factor-I (IGF-I) messenger RNA (mRNA) is expressed in Leydig cells and that IGF-I can enhance androgen production, whereas interleukin-1 (IL-1) is a potent inhibitor of Leydig cell steroidogenesis. Molecular cloning studies have confirmed the existence of at least two species of IL-1: IL-1 alpha and IL-1… CONTINUE READING