Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival.

@article{Farhadieh2004DownregulationOK,
  title={Down-regulation of KAI1/CD82 protein expression in oral cancer correlates with reduced disease free survival and overall patient survival.},
  author={Ross Darius Farhadieh and Robert Ian Smee and Kim K Ow and Jia Lin Yang and P. J. Russell and Roger Crouch and Paul Jackson and Ian V Jacobson},
  journal={Cancer letters},
  year={2004},
  volume={213 1},
  pages={91-8}
}
Oral Squamous Cell Carcinoma (OSCC) is a common malignancy. Treatment failure is mainly due to loco-regional disease recurrence. KAI1 is a newly discovered metastasis suppressor gene. Fifty-seven patients with primary OSCC underwent surgery alone or surgery and adjuvant radiotherapy. Immunohistochemical evaluation of KAI1/CD82 and p53 proteins was carried out on specimen obtained at surgery. Within neoplastic fields, KAI1/CD82 expression was downregulated and negative in 42/57 (73.7%) cases… CONTINUE READING
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