Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers.

@article{Zhou2009DownregulationOG,
  title={Down-regulation of GRIM-19 expression is associated with hyperactivation of STAT3-induced gene expression and tumor growth in human cervical cancers.},
  author={Ying Zhou and Min Li and Ying Wei and Dingqing Feng and Cheng Peng and Haiyan Weng and Yang Ma and Liang Bao and Shreeram C. Nallar and Sudhakar Kalakonda and Weihua Xiao and Dhananjaya V. Kalvakolanu and Bin Ling},
  journal={Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research},
  year={2009},
  volume={29 10},
  pages={
          695-703
        }
}
Cervical cancer is the most common malignant disease responsible for the deaths of a large number of women in the developing world. Although certain strains of human papillomavirus (HPV) have been identified as the cause of this disease, events that lead to formation of malignant tumors are not fully clear. STAT3 is a major oncogenic transcription factor involved in the development and progression of a number of human tumors. However, the mechanisms that result in loss of control over STAT3… CONTINUE READING

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