Down-regulation of GAP-43 During Oligodendrocyte Development and Lack of Expression by Astrocytes In Vivo: Implications for Macroglial Differentiation.

@article{Curtis1991DownregulationOG,
  title={Down-regulation of GAP-43 During Oligodendrocyte Development and Lack of Expression by Astrocytes In Vivo: Implications for Macroglial Differentiation.},
  author={R. B. Curtis and R Kristoffer Hardy and Richard Reynolds and Barbara A. Spruce and Graham P. Wilkin},
  journal={The European journal of neuroscience},
  year={1991},
  volume={3 9},
  pages={876-86}
}
The discovery of molecular markers which are selectively expressed during the development of specific classes of rat central nervous system macroglia has greatly advanced our understanding of how these cells are related. In particular, it has been shown in tissue culture that oligodendrocytes and some astrocytes (type-2) may be derived from a common progenitor cell (O-2A progenitor). However, the existence of type-2 astrocytes in vivo has yet to be unequivocally established. Recently, it has… CONTINUE READING

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