Down-regulation of EZH2 by RNA interference inhibits proliferation and invasion of ACHN cells via the Wnt/β- catenin pathway.

@article{Yuan2012DownregulationOE,
  title={Down-regulation of EZH2 by RNA interference inhibits proliferation and invasion of ACHN cells via the Wnt/β- catenin pathway.},
  author={Jun-Bin Yuan and Luo-yan Yang and Zheng-yan Tang and Xiong-bing Zu and Lin Qi},
  journal={Asian Pacific journal of cancer prevention : APJCP},
  year={2012},
  volume={13 12},
  pages={
          6197-201
        }
}
Although enhancer of zeste homolog 2 (EZH2) has been reported as an independent prognostic factor in renal cell carcinoma (RCC), little is known about the exact mechanism of EZH2 in promoting the genesis of RCC. However, several studies have shown that dysregulation of the Wnt/β-catenin signaling pathway plays a crucial role. Therefore, we determined whether EZH2 could affect ACHN human RCC cell proliferation and invasion via the Wnt/β-catenin pathway. In the present study, we investigated the… CONTINUE READING

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