Down-regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca(2+) into hypertensive arterial smooth muscle.

@article{Tajada2013DownregulationOC,
  title={Down-regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca(2+) into hypertensive arterial smooth muscle.},
  author={Sendoa Tajada and Pilar Cidad and Olaia Colinas and L Fernando Santana and Jos{\'e} R L{\'o}pez-L{\'o}pez and M Teresa P{\'e}rez-Garc{\'i}a},
  journal={The Journal of physiology},
  year={2013},
  volume={591 24},
  pages={
          6175-91
        }
}
Hypertension is a clinical syndrome characterized by increased arterial tone. Although the mechanisms are varied, the generally accepted view is that increased CaV1.2 channel function is a common feature of this pathological condition. Here, we investigated the mechanisms underlying vascular dysfunction in a mouse model of genetic hypertension. Contrary to expectation, we found that whole-cell CaV1.2 currents (ICa) were lower in hypertensive (BPH line) than normotensive (BPN line) myocytes… CONTINUE READING
3
Twitter Mentions

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Unravelling the complexities of vascular smooth muscle ion channels: Fine tuning of activity by ancillary subunits.

  • Pharmacology & therapeutics
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 52 REFERENCES

Constitutively active L-type Ca2+ channels.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 5 EXCERPTS