Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease.

@article{Vlad2009DownregulationOC,
  title={Down-regulation of CXCR4 and CD62L in chronic lymphocytic leukemia cells is triggered by B-cell receptor ligation and associated with progressive disease.},
  author={Amalia Vlad and Pierre-Antoine Deglesne and R{\'e}mi Letestu and St{\'e}phane Saint-Georges and Nathalie Chevallier and Fanny Baran-Marszak and Nadine Varin-Blank and Florence Ajchenbaum-Cymbalista and Dominique Ledoux},
  journal={Cancer research},
  year={2009},
  volume={69 16},
  pages={6387-95}
}
Progressive cases of B-cell chronic lymphocytic leukemia (CLL) are frequently associated with lymphadenopathy, highlighting a critical role for signals emanating from the tumor environment in the accumulation of malignant B cells. We investigated on CLL cells from 30 untreated patients the consequence of B-cell receptor (BCR) triggering on the membrane expression of CXCR4 and CD62L, two surface molecules involved in trafficking and exit of B-lymphocytes from lymph nodes. BCR stimulation… CONTINUE READING

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