Down-regulation of CXCL5 inhibits squamous carcinogenesis.

  title={Down-regulation of CXCL5 inhibits squamous carcinogenesis.},
  author={Hiroshi Miyazaki and Vyomesh S. Patel and Huixin Wang and Ryan K Edmunds and J. Silvio Gutkind and W A Yeudall},
  journal={Cancer research},
  volume={66 8},
We report a novel role for the CXC-chemokine, CXCL5, in the proliferation and invasion of head and neck squamous cell carcinoma (HNSCC). Previously, we reported transcriptional up-regulation of CXCL5 in metastatic cells. In this study, we provide biological validation of these findings and show that CXCL5 is intimately involved in tumor cell proliferation, migration, and invasion. Cells derived from a lymph node metastasis, but not from a synchronous primary tumor, secreted CXCL5 as judged by… CONTINUE READING


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