Down-regulation of C/EBPalpha in breast cancer cells by hypoxia-estrogen combination is mainly due to hypoxia.

@article{Seifeddine2009DownregulationOC,
  title={Down-regulation of C/EBPalpha in breast cancer cells by hypoxia-estrogen combination is mainly due to hypoxia.},
  author={Ramzi Seifeddine and Marie-Claude Fulchignoni-Lataud and Liliane Massaad-Massade},
  journal={Anticancer research},
  year={2009},
  volume={29 4},
  pages={1227-31}
}
CCAAT/enhancer binding protein-alpha (C/EBPalpha) is involved in the control of cell differentiation and proliferation. It has been previously shown that hypoxia (H) down-regulates C/EBPalpha in breast cancer cells; here the effect of estrogen (E(2)) during H on C/EBPalpha in T-47D cell line was examined. By quantitative RT-PCR the C/EBPalpha mRNA stability… CONTINUE READING