Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells

@inproceedings{Wu2014DownregulationOB,
  title={Down-regulation of BTG1 by miR-454-3p enhances cellular radiosensitivity in renal carcinoma cells},
  author={Xin Wu and Nan Ding and Wentao Hu and Jinpeng He and Shuai Xu and Hailong Pei and Junrui Hua and Guangming Zhou and Jufang Wang},
  booktitle={Radiation oncology},
  year={2014}
}
BACKGROUND B cell translocation gene 1 (BTG1) has long been recognized as a tumor suppressor gene. Recent reports demonstrated that BTG1 plays an important role in progression of cell cycle and is involved in cellular response to stressors. However, the microRNAs mediated regulatory mechanism of BTG1 expression has not been reported so far. MicroRNAs can effectively influence tumor radiosensitivity by preventing cell cycle progression, resulting in enhancement of the cytotoxicity of… CONTINUE READING

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