Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription.

@article{Stein2001DownregulationOB,
  title={Down-regulation of BOB.1/OBF.1 and Oct2 in classical Hodgkin disease but not in lymphocyte predominant Hodgkin disease correlates with immunoglobulin transcription.},
  author={Harald Stein and Teresa Marafioti and H. D. Foss and Helmut Laumen and Michael Hummel and Ioannis K. Anagnostopoulos and Thomas Wirth and G Demel and Brunangelo Falini},
  journal={Blood},
  year={2001},
  volume={97 2},
  pages={496-501}
}
In contrast to the tumor cells (L&H cells) of lymphocyte predominant Hodgkin disease (LPHD), Hodgkin and Reed-Sternberg (HRS) cells of classical Hodgkin disease (cHD) are unable to transcribe immunoglobulin, despite the presence of rearranged immunoglobulin genes. Although initial studies have suggested crippling immunoglobulin gene mutations to be the cause of absent immunoglobulin expression in cHD, recent work of our group has demonstrated an impaired activation of the immunoglobulin… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 81 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 34 references

The nature of Reed-Sternberg cells, lymphocytic and histiocytic cells and their molecular biology in Hodgkin’s disease

  • H Stein, V Diehl, T Marafioti, A Jox, J Wolf, M. Hummel
  • 1999

Similar Papers

Loading similar papers…