Down-regulation of 8-hydroxydeoxyguanosine and peroxiredoxin II in the pathogenesis of endometriosis-associated ovarian cancer.

@article{Sova2012DownregulationO8,
  title={Down-regulation of 8-hydroxydeoxyguanosine and peroxiredoxin II in the pathogenesis of endometriosis-associated ovarian cancer.},
  author={Henri Sova and Juha Kangas and Ulla S Puistola and Markku J Santala and Annikki K Liakka and Peeter Karihtala},
  journal={Anticancer research},
  year={2012},
  volume={32 8},
  pages={3037-44}
}
AIM To evaluate the roles of oxidative stress marker 8-hydroxydeoxyguanosine (8-OHdG) and peroxiredoxin (PRX) antioxidants in the development of endometriosis and endometriosis-associated ovarian cancer (EAC). MATERIALS AND METHODS Tissue expressions of 8-OHdG, PRX II and PRX IV were determined immunohistochemically in tissue from 22 women with benign endometriosis (BE) and 33 women with EAC, among whom endometriosis and cancer tissues were analyzed separately. RESULTS When all three groups… CONTINUE READING